The first time I whipped up a dish featuring Cajun shrimp and salmon, I was honestly just trying to use up some ingredients in my fridge. But what started as a practical cooking session quickly turned into a revelation. The smoky, spicy kick of Cajun seasoning paired with the rich, flaky salmon and succulent shrimp, all brought together by a silky garlic cream sauce… it was magic. This isn’t just a meal; it’s an experience, a little escape to the bayou from your own kitchen. And the best part? It’s far less intimidating to create than it sounds.
Why You’ll Love This Dish
This Cajun Shrimp and Salmon with Garlic Cream Sauce isn’t just another dinner recipe; it’s a culinary journey. You’ll adore it because it effortlessly combines sophisticated flavors with straightforward cooking. It’s perfect for a special date night or when you want to impress guests without spending hours in the kitchen. The dish strikes a beautiful balance between indulgence and zest, making it incredibly satisfying. Plus, seafood cooks quickly, meaning you can have a gourmet-level meal on your table faster than you might think. It’s a fantastic way to elevate a weeknight dinner, turning an ordinary evening into something truly memorable.
> “This recipe completely changed my mind about cooking seafood at home. The flavors are incredible, and the garlic cream sauce is to die for! My family requests it constantly now.” – A Satisfied Home Cook
The Cooking Process Explained
Making Cajun Shrimp and Salmon with Garlic Cream Sauce involves a few key stages that build incredible flavor. First, you’ll season your salmon and shrimp generously with Cajun spices, giving them that signature zesty kick. Then, the seafood gets a quick sear, locking in moisture and creating a beautiful crust. While the seafood rests, you’ll whip up the star of the show: a luscious garlic cream sauce, often built on the pan drippings for extra depth. Finally, everything comes together, often with a quick simmer in the sauce or a drizzle over the top, resulting in a harmonious and deeply satisfying meal.
Gather These Items
To embark on this flavorful adventure, here’s what you’ll need:
- Salmon fillets: About 6oz each, skin on or off depending on your preference.
- Large shrimp: Peeled and deveined, tail-on for presentation, or off for convenience.
- Cajun seasoning: Your favorite blend – store-bought or homemade.
- Olive oil or butter: For searing.
- Garlic: Plenty of minced fresh garlic.
- Heavy cream: The base for your luxurious sauce.
- Chicken or vegetable broth: To thin the sauce slightly and add savory notes.
- Parmesan cheese: Freshly grated, to enrich the sauce.
- Fresh parsley or chives: For garnish and a burst of freshness.
- Lemon: For a squeeze at the end – it brightens all the flavors.
- Optional for a kick: A pinch of cayenne pepper or a dash of hot sauce in the cream.
Directions to Follow
Let’s get cooking! Here’s how to bring this amazing dish to life:
- Prep the seafood: Pat both salmon fillets and shrimp dry with paper towels. Season generously all over with Cajun seasoning.
- Sear the salmon: Heat oil or butter in a large skillet over medium-high heat. Place salmon skin-side down (if applicable) and sear for 4-6 minutes per side, depending on thickness, until cooked to your liking. Remove from skillet and set aside.
- Cook the shrimp: Add a little more oil if needed. Add shrimp to the hot skillet and cook for 2-3 minutes per side, until pink and opaque. Remove from skillet and set aside.
- Make the sauce: Lower heat to medium. Add minced garlic to the skillet and sauté for 1 minute until fragrant. Pour in heavy cream and broth, scraping up any browned bits from the bottom of the pan. Bring to a gentle simmer.
- Finish the sauce: Stir in grated Parmesan cheese until melted and the sauce thickens slightly. If desired, add a pinch of cayenne or hot sauce for extra heat.
- Combine and serve: Return the cooked shrimp to the skillet with the sauce, tossing to coat. You can either place the seared salmon directly into the sauce for a moment to warm through, or simply serve the salmon on plates and spoon the garlic cream shrimp mixture over the top. Garnish with fresh parsley or chives and a squeeze of fresh lemon juice.
Best Ways to Enjoy It
This Cajun Shrimp and Salmon with Garlic Cream Sauce is incredibly versatile. For a complete meal, serve it atop a bed of fluffy white rice, creamy polenta, or even mashed potatoes to soak up every last drop of that incredible sauce. If you’re looking for a lighter option, it pairs beautifully with steamed asparagus, green beans, or a simple side salad with a vinaigrette dressing. The vibrant colors of the salmon and shrimp, along with the creamy white sauce and green herbs, make for a visually stunning plate that’s sure to impress.
Keeping Leftovers Fresh
Should you be lucky enough to have any leftovers, proper storage is key to maintaining quality and safety. Allow the dish to cool completely before transferring it to an airtight container. It will keep well in the refrigerator for up to 2-3 days. When reheating, gently warm it on the stovetop over low heat, or in the microwave in short bursts, until just heated through. Be careful not to overheat the seafood, as it can become tough. I don’t generally recommend freezing this dish, as dairy-based sauces can sometimes separate upon thawing, and seafood textures can degrade.
Helpful Cooking Tips
- Don’t overcrowd the pan: When searing the salmon and shrimp, cook in batches if necessary. Overcrowding lowers the pan temperature, leading to steaming instead of searing, and you’ll miss out on that beautiful crust.
- Pat seafood dry: This is crucial for a good sear. Moisture on the surface will create steam and prevent browning.
- Don’t overcook the seafood: Salmon should be cooked to an internal temperature of 145°F (63°C) for flakiness, and shrimp turn pink and opaque when done. Overcooked seafood becomes rubbery and dry.
- Taste and adjust: Always taste your sauce before it’s finished. Adjust seasoning, adding more Cajun blend, salt, or even a touch more lemon juice if needed.
- Fresh garlic makes a difference: While garlic powder can work in a pinch, fresh minced garlic provides a much more vibrant and aromatic flavor to the cream sauce.
Creative Twists
This recipe is a fantastic starting point for innovation!
- Spicy Kick: Amp up the heat by incorporating a finely diced jalapeño or serrano pepper into the garlic while sautéing, or add a pinch of smoked paprika to the Cajun seasoning.
- Herbaceous Boost: Experiment with other fresh herbs like fresh dill or tarragon for a different flavor profile in the cream sauce.
- Veggie Power: Sauté some chopped bell peppers or spinach with the garlic before adding the cream for a more substantial meal.
- Pasta Perfection: Toss the finished shrimp and salmon with the garlic cream sauce into cooked pasta for a decadent seafood pasta dish.
- Smoked Paprika Depth: A tiny pinch of smoked paprika in the Cajun seasoning blend (or added to the sauce) can deepen the flavor profile beautifully.
- Different Cheeses: While Parmesan is classic, a touch of aged white cheddar or even some crumbled goat cheese could add an interesting twist to the sauce.
Your Questions Answered
FAQ
Q: Can I use frozen salmon and shrimp?
A: Absolutely! Just make sure to completely thaw them according to package directions before patting them dry and seasoning. Excess moisture from thawing will prevent a good sear.
Q: I don’t have heavy cream. Can I use something else?
A: Heavy cream provides the richest texture. While you can try half-and-half or even evaporated milk, the sauce won’t be as thick or luxurious. Avoid regular milk, as it’s prone to curdling when heated with acids like lemon.
Q: How spicy is “Cajun Shrimp and Salmon”?
A: The spice level largely depends on your chosen Cajun seasoning blend. Some are milder, while others pack a significant punch. You can always start with a little less seasoning and add more cayenne pepper or hot sauce directly to the cream sauce if you prefer more heat. When buying, check the ingredient list for chili content, or make your own to control the spice!

Spicy Cajun Shrimp and Salmon with Creamy Garlic Sauce
Equipment
- Small bowl
- Large skillet or cast-iron pan
Ingredients
Cajun Seasoning
- 1 tablespoon smoked paprika
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon dried oregano
- 1 teaspoon dried thyme
- ½ teaspoon cayenne pepper adjust to your spice preference
- ½ teaspoon black pepper
- ½ teaspoon salt
Seafood
- 2 (6-ounce) salmon fillets skin on or off
- 1 pound large shrimp peeled and deveined
- 2 tablespoons olive oil divided
Creamy Garlic Sauce
- 2 tablespoons unsalted butter
- 4-5 cloves garlic minced
- 1 ½ cups heavy cream
- ½ cup chicken or vegetable broth
- ¼ cup grated Parmesan cheese
Garnish & Seasoning
- 2 tablespoons fresh parsley chopped, for garnish
- Salt and black pepper to taste
Instructions
Prepare Cajun Seasoning
- In a small bowl, combine smoked paprika, garlic powder, onion powder, oregano, thyme, cayenne pepper, black pepper, and salt; mix well.
Season Seafood
- Pat the salmon and shrimp dry, then sprinkle 1-2 tablespoons of the Cajun seasoning evenly over them, ensuring they are well coated. Set aside any remaining seasoning.
Cook Salmon
- Heat 1 tablespoon of olive oil in a large skillet over medium-high heat. Cook salmon for 4-6 minutes per side until cooked through and flaky, then remove and set aside.
Cook Shrimp
- Add the remaining 1 tablespoon of olive oil to the same skillet. Cook shrimp for 2-3 minutes per side until pink and opaque, then remove and set aside with the salmon.
Make Garlic Cream Sauce
- Reduce heat to medium, melt butter in the skillet, and sauté minced garlic for about 1 minute until fragrant.
Simmer Sauce
- Pour in heavy cream and chicken or vegetable broth. Bring to a gentle simmer, stirring occasionally, and cook for 5-7 minutes until the sauce slightly thickens.
Finish Sauce
- Stir in Parmesan cheese until melted and smooth. Season with additional salt, pepper, and remaining Cajun seasoning if desired.
Combine and Serve
- Return cooked salmon and shrimp to the skillet with the sauce. Gently spoon sauce over seafood, garnish with fresh chopped parsley, and serve immediately.
